Retraction: Bmi1 limits dilated cardiomyopathy and heart failure by inhibiting cardiac senescence

نویسندگان

  • I Gonzalez-Valdes
  • I Hidalgo
  • A Bujarrabal
  • E Lara-Pezzi
  • L Padron-Barthe
  • P Garcia-Pavia
  • Pablo Gómez-del Arco
  • J M Redondo
  • J M Ruiz-Cabello
  • L J Jimenez-Borreguero
  • J A Enriquez
  • J L de la Pompa
  • A Hidalgo
  • S Gonzalez
چکیده

We the authors are retracting this Article as it has come to our attention that there has been inappropriate duplication of images between different figures of the published paper, and between figures in the paper and those in work previously published by the corresponding author (Hidalgo, I. et al. 2012). The figure panels affected are Figure 1d, Figure 3c, Figure 4e, Figures 6a, g, and Supplementary Figure 1b. The corresponding author, S. Gonzalez, was unable to supply a complete set of raw data on which the Article is based. The Centro Nacional de Investigaciones Cardiovasculares Carlos III and the first author I. Gonzalez-Valdes, together with the co-authors I. Hidalgo, A. Bujarrabal, E. Lara-Pezzi, L. Padron-Barthe, P. Garcia-Pavia, Pablo Gómez-del Arco, J.M. Redondo, J.M. Ruiz-Cabello, L.J. Jimenez-Borreguero, J.A. Enriquez, J.L. de la Pompa, and A. Hidalgo, agree with retraction of the Article.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Bmi1 limits dilated cardiomyopathy and heart failure by inhibiting cardiac senescence

Dilated cardiomyopathy (DCM) is the most frequent cause of heart failure and the leading indication for heart transplantation. Here we show that epigenetic regulator and central transcriptional instructor in adult stem cells, Bmi1, protects against DCM by repressing cardiac senescence. Cardiac-specific Bmi1 deletion induces the development of DCM, which progresses to lung congestion and heart f...

متن کامل

Senescence and death of primitive cells and myocytes lead to premature cardiac aging and heart failure.

Chronological myocardial aging is viewed as the inevitable effect of time on the functional reserve of the heart. Cardiac failure in elderly patients is commonly interpreted as an idiopathic or secondary myopathy superimposed on the old heart independently from the aging process. Thus, aged diseased hearts were studied to determine whether cell regeneration was disproportionate to the accumulat...

متن کامل

Atrial natriuretic peptide affects cardiac remodeling, function, heart failure, and survival in a mouse model of dilated cardiomyopathy.

Dilated cardiomyopathy is a frequent cause of heart failure and death. Atrial natriuretic peptide (ANP) is a biomarker of dilated cardiomyopathy, but there is controversy whether ANP modulates the development of heart failure. Therefore, we examined whether ANP affects heart failure, cardiac remodeling, function, and survival in a well-characterized, transgenic model of dilated cardiomyopathy. ...

متن کامل

Evaluation of transesophageal echocardiography in detecting cardiac sources of emboli in ischemic stroke patients

  Background: Embolus is one of the causes of ischemic stroke that can be due to cardiac sources such as valvular heart diseases and atrial fibrillation and atheroma of the aorta. Transesophageal echocardiography (TEE) is superior in identifying potential cardiac sources of emboli. Due to insufficient data on TEE findings in ischemic stroke in Iran, the present study was done to evaluate TEE in...

متن کامل

Corin overexpression improves cardiac function, heart failure, and survival in mice with dilated cardiomyopathy.

Heart failure, caused by dilated cardiomyopathy and other cardiac disorders such as hypertension, is a major public health problem with high morbidity and mortality. Corin, a cardiac enzyme that cleaves natriuretic peptides, is a promising biomarker of cardiomyopathy and heart failure, but its functional role in these processes is not understood. We evaluated the potential effects of corin in m...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره 8  شماره 

صفحات  -

تاریخ انتشار 2017